Perfusion Imaging of Traumatic Brain Injury

Nathan W Churchill; Simon J Graham; Tom A Schweizer

doi:10.1016/j.nic.2023.01.006

Perfusion Imaging of Traumatic Brain Injury

Neuroimaging Clin N Am. 2023 May;33(2):315-324. doi: 10.1016/j.nic.2023.01.006.

Authors

Nathan W Churchill¹, Simon J Graham², Tom A Schweizer³

Affiliations

¹ Neuroscience Research Program, Saint Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1M8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1M8, Canada; Physics Department, Toronto Metropolitan University, 60 St George St, Toronto, ON M5S 1A7, Canada. Electronic address: nathan.churchill@unityhealth.to.
² Department of Medical Biophysics, University of Toronto, 101 College Street, Suite 15-701, Toronto, ON M5G 1L7, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Wellness Way, Toronto, ON M4N 3M5, Canada; Physical Sciences Platform, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
³ Neuroscience Research Program, Saint Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1M8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1M8, Canada; Faculty of Medicine (Neurosurgery), University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

PMID: 36965948
DOI: 10.1016/j.nic.2023.01.006

Abstract

The mechanisms for regulating cerebral blood flow (CBF) are highly sensitive to traumatic brain injury (TBI). The perfusion imaging technique may be used to assess CBF and identify perfusion abnormalities following a TBI. Studies have identified CBF disturbances across the injury severity spectrum and correlations with both acute and long-term indices of clinical outcome. Although not yet widely used in the clinical context, this is an important area of ongoing research.

Keywords: CT; Cerebral blood flow; Concussion; MRI; Perfusion; TBI.

Publication types

Review

MeSH terms

Brain
Brain Injuries, Traumatic* / diagnostic imaging
Cerebrovascular Circulation / physiology
Humans
Magnetic Resonance Imaging
Perfusion Imaging