Local narrow margin excision sequential with modified ALA-PDT for successful treatment of an 86-year-old patient with malignant proliferating trichilemmal tumor

Mingshun Wu; Caihe Liao; Zijun Zhao; Zhongxia Zhou; Yeqiang Liu; Xiuli Wang; Guolong Zhang

doi:10.1016/j.pdpdt.2023.103524

Local narrow margin excision sequential with modified ALA-PDT for successful treatment of an 86-year-old patient with malignant proliferating trichilemmal tumor

Photodiagnosis Photodyn Ther. 2023 Jun:42:103524. doi: 10.1016/j.pdpdt.2023.103524. Epub 2023 Mar 23.

Authors

Mingshun Wu¹, Caihe Liao¹, Zijun Zhao¹, Zhongxia Zhou¹, Yeqiang Liu², Xiuli Wang³, Guolong Zhang⁴

Affiliations

¹ Institute of Photomedicine Shanghai Skin Disease Hospital School of Medicine, Tongji University, Shanghai 200443, China; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.
² Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China; Department of Pathology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.
³ Institute of Photomedicine Shanghai Skin Disease Hospital School of Medicine, Tongji University, Shanghai 200443, China; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China. Electronic address: wangxiuli_1400023@tongji.edu.cn.
⁴ Institute of Photomedicine Shanghai Skin Disease Hospital School of Medicine, Tongji University, Shanghai 200443, China; Skin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China. Electronic address: glzhangtj@tongji.edu.cn.

PMID: 36965758
DOI: 10.1016/j.pdpdt.2023.103524

Abstract

Malignant proliferating trichilemmal tumor (MPTT) is thought to represent the malignant counterpart of benign proliferative pilar cyst, a lesion originating from the outer hair root sheath. We report a case of an 86-year-old woman with an exophytic nodule containing an ulcerated surface in the temporal region. Histopathologically confirmed MPTT without metastasis, and considering the risk of metastasis and recurrence, we used single local narrow margin excision combined with modified 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). No recurrence of skin lesions was found in the 2-year follow-up after combined therapy. In conclusion, local narrow margin excision sequential with modified ALA-PDT may be a particularly promising and effective treatment option for MPTT.

Keywords: Ala-pdt; Local excision; Malignant proliferating trichilemmal tumor; Photodynamic therapy.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Aminolevulinic Acid / therapeutic use
Female
Humans
Photochemotherapy* / methods
Photosensitizing Agents / therapeutic use
Precancerous Conditions*
Skin Neoplasms* / drug therapy
Skin Neoplasms* / pathology
Skin Neoplasms* / surgery
Treatment Outcome

Substances

Photosensitizing Agents
Aminolevulinic Acid