Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy

Nastaran Masoudi-Khoram; Mohammad Hasan Soheilifar; Shima Ghorbanifar; Sima Nobari; Maryam Hakimi; Mahmoud Hassani

doi:10.1016/j.critrevonc.2023.103967

Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy

Crit Rev Oncol Hematol. 2023 May:185:103967. doi: 10.1016/j.critrevonc.2023.103967. Epub 2023 Mar 23.

Authors

Nastaran Masoudi-Khoram¹, Mohammad Hasan Soheilifar², Shima Ghorbanifar³, Sima Nobari⁴, Maryam Hakimi⁵, Mahmoud Hassani⁶

Affiliations

¹ Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
² Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran. Electronic address: Soheilih@gmail.com.
³ Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.
⁴ Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
⁵ Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
⁶ Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 36965647
DOI: 10.1016/j.critrevonc.2023.103967

Abstract

Cancer-associated fibroblasts (CAFs) are the prominent stromal cell population in the tumor microenvironment (TME), which play an indispensable role in cancer progression and response to therapy. CAFs provide communication between tumor cells and surrounding cells by secreting soluble biomolecules and extracellular vesicles (EVs). Exosomes are small membrane-bound EVs that contain various cargos, including growth factors, non-coding RNAs (ncRNAs), cytokines, and chemokines. These biomolecules can be transferred between cells within the TME and alter the behavior of recipient cells. Some studies have shown that exosomes secreted by CAFs contribute to resistance to chemotherapy and radiotherapy. This review focuses on CAF-derived exosomes in different types of tumors, with emphasis on resistance to chemotherapy and radiotherapy.

Keywords: Cancer-associated fibroblast; Chemotherapy resistance; Exosome; Radiation resistance; Tumor microenvironment.

Publication types

Review

MeSH terms

Cancer-Associated Fibroblasts* / pathology
Cell Communication
Exosomes* / metabolism
Fibroblasts / metabolism
Humans
Neoplasms* / pathology
Tumor Microenvironment