Withanolides from Discopodium penninervium

Kibrom Gebreheiwot Bedane; Mekonnen Abebayehu Desta; Peter Spiteller

doi:10.1016/j.fitote.2023.105478

Withanolides from Discopodium penninervium

Fitoterapia. 2023 Jun:167:105478. doi: 10.1016/j.fitote.2023.105478. Epub 2023 Mar 24.

Authors

Kibrom Gebreheiwot Bedane¹, Mekonnen Abebayehu Desta², Peter Spiteller³

Affiliations

¹ Department of Chemistry, Addis Ababa University, P.O. Box 33658, Addis Ababa, Ethiopia; Faculty of Biology and Chemistry, Institute for Organic and Analytical Chemistry, University of Bremen, Leobener Straße 7, D-28359 Bremen, Germany. Electronic address: kibrom.gebreheiwot@aau.edu.et.
² Department of Chemistry, Addis Ababa University, P.O. Box 33658, Addis Ababa, Ethiopia.
³ Faculty of Biology and Chemistry, Institute for Organic and Analytical Chemistry, University of Bremen, Leobener Straße 7, D-28359 Bremen, Germany. Electronic address: peter.spiteller@uni-bremen.de.

PMID: 36965582
DOI: 10.1016/j.fitote.2023.105478

Abstract

Discopodium penninervium is a medicinal plant endemic to Ethiopia. Its twigs extract led to the isolation of three new withanolides, discopodinolides A - C, and four known analogues. The structures of the compounds were elucidated using NMR, HRMS data analyses, and literature data. The relative configurations were defined by single-crystal X-ray crystallography and NOESY correlations. The antibacterial efficacy of the isolated compounds was evaluated against four commonly dispersed environmental strains of Escherichia coli, Bacillus subtilis, Bacillus pumilus, and Bacillus megaterium. Discopodinolides B and C exhibited moderate antibacterial activities against the pathogenic strains of E. coli, B. subtilis, and B. megaterium.

Keywords: Antibacterial; Discopodinolides A – C; Discopodium penninervium; Solanaceae.

MeSH terms

Anti-Bacterial Agents
Escherichia coli
Molecular Structure
Plants, Medicinal* / chemistry
Withanolides* / chemistry
Withanolides* / pharmacology

Substances

Withanolides
Anti-Bacterial Agents