Adaptive living skills, sleep problems, and mental health disorders in adults with 22q11.21 deletion syndrome

Geraldine Leader; Andrea Curtin; Robert J Shprintzen; Sally Whelan; Rory Coyne; Arlene Mannion

doi:10.1016/j.ridd.2023.104491

Adaptive living skills, sleep problems, and mental health disorders in adults with 22q11.21 deletion syndrome

Res Dev Disabil. 2023 May:136:104491. doi: 10.1016/j.ridd.2023.104491. Epub 2023 Mar 23.

Authors

Geraldine Leader¹, Andrea Curtin², Robert J Shprintzen³, Sally Whelan², Rory Coyne², Arlene Mannion²

Affiliations

¹ Irish Centre for Autism and Neurodevelopmental Research, School of Psychology, National, University of Ireland, Galway, Ireland. Electronic address: geraldine.leader@nuigalway.ie.
² Irish Centre for Autism and Neurodevelopmental Research, School of Psychology, National, University of Ireland, Galway, Ireland.
³ The Virtual Center for Velo-Cardio-Facial Syndrome, Inc, United States.

PMID: 36965410
DOI: 10.1016/j.ridd.2023.104491

Abstract

Background: 22q11.21 deletion syndrome (22q11DS) is a neurodevelopmental syndrome caused by a microdeletion of genes at the 22q11.21 locus. It has a prevalence of 1:2000. This study investigated the prevalence of adaptive living skills, sleep problems, and mental health disorders in adults with 22q11DS and examined the relationship between these factors.

Methods: Parents with an adult son or daughter with 22q11DS completed the following: A bespoke Demographic Information Questionnaire, Sleep Questionnaire (SQ-SP), Psychopathology in Autism Checklist (PAC), and Activities of Daily Living (ADL) scale. Descriptive statistics, correlations, and one-way between groups analysis of variance (ANOVA) were conducted.

Results: Mental health difficulties, sleep problems, and low levels of adaptive living skills are prevalent in adults with 22q11DS. Strong positive correlations were identified between sleep problems, depression, and anxiety subscale scores and moderate negative correlations between depression, psychosis, and activities of daily living skills.

Conclusion: Adults with 22q11DS need screening and treatment for mental health and sleep problems.

Keywords: Conotruncal anomaly face syndrome; DiGeorge syndrome; Sedlačková syndrome; Velo-cardio-facial syndrome.

MeSH terms

22q11 Deletion Syndrome*
Activities of Daily Living
Adult
DiGeorge Syndrome* / complications
DiGeorge Syndrome* / epidemiology
DiGeorge Syndrome* / genetics
Humans
Mental Disorders* / epidemiology
Mental Disorders* / genetics
Mental Health
Sleep Wake Disorders* / epidemiology
Sleep Wake Disorders* / genetics