The strange Microenvironment of Glioblastoma

L Brisson; L Henrique Geraldo; A Bikfalvi; T Mathivet

doi:10.1016/j.neurol.2023.03.007

The strange Microenvironment of Glioblastoma

Rev Neurol (Paris). 2023 Jun;179(5):490-501. doi: 10.1016/j.neurol.2023.03.007. Epub 2023 Mar 22.

Authors

L Brisson¹, L Henrique Geraldo², A Bikfalvi³, T Mathivet¹

Affiliations

¹ BRIC Inserm U1312, Université de Bordeaux, 33615 Pessac, France.
² Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
³ BRIC Inserm U1312, Université de Bordeaux, 33615 Pessac, France. Electronic address: andreas.bikfalvi@u-bordeaux.fr.

PMID: 36964121
DOI: 10.1016/j.neurol.2023.03.007

Abstract

Glioblastoma (GB) is the most common and aggressive primary brain tumor, with poor patient survival and lack of effective therapies. Late advances trying to decipher the composition of the GB tumor microenvironment (TME) emphasized its role in tumor progression and potentialized it as a therapeutic target. Many components participate critically to tumor development and expansion such as blood vessels, immune cells or components of the nervous system. Dysmorphic tumor vasculature brings challenges to optimal delivery of cytotoxic agents currently used in clinics. Also, massive infiltration of immunosuppressive myeloid cells and limited recruitment of T cells limits the success of conventional immunotherapies. Neuronal input seems also be required for tumor expansion. In this review, we provide a comprehensive report of vascular and immune component of the GB TME and their cross talk during GB progression.

Keywords: Glioblastoma; Immunity; Microenvironment; Vasculature.

Publication types

Review

MeSH terms

Brain Neoplasms* / therapy
Glioblastoma* / drug therapy
Humans
Tumor Microenvironment