Immune checkpoint inhibitor-related thyroid dysfunction

Ann Endocrinol (Paris). 2023 May;84(3):346-350. doi: 10.1016/j.ando.2023.03.005. Epub 2023 Mar 22.

Abstract

Immune checkpoint inhibitors (ICIs) are currently the key therapy for several cancers. Among immune-related adverse events, thyroid dysfunction is the most frequent. We review this thyroid dysfunction, with recent data on epidemiology, diagnostic considerations, management and risk factors.

Keywords: Dysfonction thyroïdienne; Hypothyroidism; Hypothyroïdie; Immune checkpoint inhibitors; Inhibiteurs des points de contrôle immunitaire; Thyroid dysfunction; Thyroiditis; Thyrotoxicose; Thyrotoxicosis; Thyroïdite.

Publication types

  • Review

MeSH terms

  • Humans
  • Immune Checkpoint Inhibitors* / adverse effects
  • Thyroid Diseases* / chemically induced
  • Thyroid Diseases* / therapy

Substances

  • Immune Checkpoint Inhibitors