Association between organophosphorus insecticides exposure and the prevalence of sleep problems in the US adults: An analysis based on the NHANES 2007-2018

Abstract

Objective: The aim of this study was to evaluate the association between organophosphorus pesticides (OPPs) exposure and sleep problems.

Methods: In this study, data from 6295 participants aged 18 years or older were collected from the National Health and Nutrition Examination Survey (NHANES). The dialkyl phosphate compounds (DAPs) metabolites, OPPs exposure biomarker, were examined using solid phase extraction-high coupled with isotope dilution-ultrahigh performance liquid chromatography-tandem mass spectrometry. Data on short sleep duration (SSD), self-reported trouble sleeping and self-reported sleep disorder were collected from the database. Weighted generalized logistic model, weighted quantile sum (WQS) model, and quantile-based g calculation (QGC) methods were used for analyzing the collected data.

Results: The prevalence of SSD, self-reported trouble sleeping and self-reported sleep disorder in this study were 28.91 % (1814/6274), 25.31 % (1593/6294), and 9.05 % (289/3195), respectively. After confounding factors adjustments, the prevalence of SDD in participants with high log-transformed DETP, DMTP, DEDTP, and DMDTP were 1.19 times (OR: 1.11-1.28, P < 0.001), 1.09 times (OR: 1.03-1.15, P = 0.003), 1.26 times (OR: 1.17-1.37, P < 0.0001), and 1.10 times (OR: 1.04-1.17, P = 0.003) than in participants with low showed, respectively. A non-linear relationship was noted between SSD with the urinary concentration of DEP (P for nonlinearity < 0.001), DMP (P for nonlinearity < 0.001), DMTP (P for nonlinearity = 0.006), and DMDTP (P for nonlinearity = 0.001). The WQS results showed that the prevalence of SDD was 1.28 times (95 % CI: 1.17-1.40, P < 0.001) higher in participants with high co-exposure to OPPs than in those with low co-exposure, with DEDTP having the enormous weights (0.50). The QGC results also revealed a significant positive association between the co-exposure of DAPs and SSD (OR: 1.08, 95 % CI:1.02-1.16, P = 0.01) with DETP having the most positive weight (0.44). As for the association between DAPs with self-report sleep disorder, only DEP was detected that it was positively associated with self-reported sleep disorder with all confounding factors adjusted (OR: 1.17; 95 % CI: 1.07-1.29, P = 0.001). However, all DAPs have not detected a significant association with the prevalence of self-reported trouble sleeping. Besides, there was no significant association between co-exposure to OPPs with self-reported trouble sleeping and self-reported sleep disorder.

Conclusion: The results of this study indicated that high levels of single or mixture urinary DAP, indicating for OPPs exposure, were associated with an increased prevalence of SSD in general adults, which has significant implications for preventing OPPs pollution and protecting sleep health.

Keywords: Cross-sectional study; Dose-response relationship; Organophosphorus insecticides; Short sleep duration.