The contribution of mitochondria-associated endoplasmic reticulum membranes (MAMs) dysfunction in Alzheimer's disease and the potential countermeasure

Zehui Li; Yu Cao; Hui Pei; Lina Ma; Yang Yang; Hao Li

doi:10.3389/fnins.2023.1158204

The contribution of mitochondria-associated endoplasmic reticulum membranes (MAMs) dysfunction in Alzheimer's disease and the potential countermeasure

Front Neurosci. 2023 Mar 7:17:1158204. doi: 10.3389/fnins.2023.1158204. eCollection 2023.

Authors

Zehui Li¹, Yu Cao¹, Hui Pei¹, Lina Ma¹, Yang Yang¹, Hao Li^{1

2}

Affiliations

¹ Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
² Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease. There are many studies targeting extracellular deposits of amyloid β-peptide (Aβ) and intracellular neurofibrillary tangles (NFTs), however, there are no effective treatments to halt the progression. Mitochondria-associated endoplasmic reticulum membranes (MAMs) have long been found to be associated with various pathogenesis hypotheses of AD, such as Aβ deposition, mitochondrial dysfunction, and calcium homeostasis. However, there is a lack of literature summarizing recent advances in the mechanism and treatment studies. Accordingly, this article reviews the latest research involving the roles of MAM structure and tethering proteins in the pathogenesis of AD and summarizes potential strategies targeting MAMs to dissect treatment perspectives for AD.

Keywords: Alzheimer’s disease; calcium homeostasis; endoplasmic reticulum; lipid metabolism; mitochondria.

Publication types

Review

Grants and funding

This work was supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes (No. ZZ15-YQ-018), the National Natural Science Foundation of China (Nos. 82205103 and 82205233), and the CACMS Innovation Fund (No. CI2021A01401).