Natural products regulate mitochondrial function in cognitive dysfunction-A scoping review

Jinmei Tuo; Yan Peng; Yushuang Linghu; Ming Tao; Shiming Huang; Zucai Xu

doi:10.3389/fphar.2023.1091879

Natural products regulate mitochondrial function in cognitive dysfunction-A scoping review

Front Pharmacol. 2023 Mar 7:14:1091879. doi: 10.3389/fphar.2023.1091879. eCollection 2023.

Authors

Jinmei Tuo^{1

2

3}, Yan Peng¹, Yushuang Linghu², Ming Tao², Shiming Huang², Zucai Xu^{1

3}

Affiliations

¹ Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
² Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
³ The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi, China.

Abstract

Medicines from natural products can not only treat neurodegenerative diseases but also improve the cognitive dysfunction caused by treatments with western medicines. This study reviews the literature related to the regulation of mitochondrial participation in cognitive function by natural products. In this study, we focused on English articles in PubMed, Web of Science, and Google Scholar, from 15 October 2017, to 15 October 2022. Fourteen studies that followed the inclusion criteria were integrated, analyzed, and summarized. Several studies have shown that natural products can improve or reduce cognitive dysfunction by ameliorating mitochondrial dysfunction. These results suggest that natural products may serve as new therapeutic targets for neurodegenerative diseases.

Keywords: cognitive dysfunction; mitochondrial function; natural products; neurodegenerative diseases; scoping review.

Publication types

Review

Grants and funding

This work was supported by grants from the Guizhou epilepsy basic and clinical research scientific and technological innovation talent team project (No: CXTD [2022]013), the Collaborative Innovation Center of Chinese Ministry of Education (No: 2020-39), the Guizhou provincial “hundred” level innovative talents funds (No: GCC-2022-038-1), the Guizhou Provincial Science and Technology Foundation (No: ZK2022-656), and the Zunyi City Science and Technology Foundation (No: 2019-71 and 2021-30).