Volumetric modulated arc therapy for hippocampal-sparing prophylactic cranial irradiation: Planning comparison of Halcyon and C-arm accelerators

Tao Sun; Xiutong Lin; Kuo Li; Qingtao Qiu; Jinghao Duan; Guifang Zhang; Yong Yin

doi:10.3389/fonc.2023.993809

Volumetric modulated arc therapy for hippocampal-sparing prophylactic cranial irradiation: Planning comparison of Halcyon and C-arm accelerators

Front Oncol. 2023 Mar 7:13:993809. doi: 10.3389/fonc.2023.993809. eCollection 2023.

Authors

Tao Sun¹, Xiutong Lin¹, Kuo Li¹, Qingtao Qiu¹, Jinghao Duan¹, Guifang Zhang¹, Yong Yin¹

Affiliation

¹ Department of Radiation Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Abstract

Background: The purpose of the study was to evaluate the dosimetry of the Halcyon in prophylactic cranial irradiation (PCI) with volumetric modulated arc therapy (VMAT) and hippocampal-sparing for small cell lung cancer (SCLC).

Methods: Five VMAT plans were designed on CT images of 15 patients diagnosed with SCLC and received PCI. Three plans with two full arcs were generated on the Trilogy and the TrueBeam accelerators, and flattening filter (FF) and flattening filter free (FFF) modes were used on TrueBeam. Two Halcyon plans with two and three full arcs were generated, referred to as H-2A and H-3A, respectively. The prescription dose was 25 Gy in 2.5-Gy fractions. The dose limit for hippocampus were D₁₀₀ ≤ 9Gy and D_max ≤ 16Gy. The Wilcoxon matched-paired signed-rank test was used to evaluate the significance of the observed differences between the five plans.

Results: H-2A plans significantly increased the D₂ of PTV, and H-3A plans showed comparable or even better target dosimetry (better conformity) compared to the three plans on C-arm accelerators. Compared to T and TB plans, the two Halcyon plans significantly reduced the D₁₀₀ and mean doses of bilateral hippocampus, the mean doses of eyeballs, and the maximum doses of lenses. D₁₀₀ of hippocampus was reduced in TrueBeam plans comparing to Trilogy plans. The FFF plans on TrueBeam also represented advantages in D_mean and D₁₀₀ of hippocampas, D_mean and D_max of eyeballs, and the D_max of lenses compared to FF plans. Halcyon plans and TrueBeam plans with FFF mode increased the MUs compared to FF plans. Comparing to H-2A, the H-3A plans exhibited additional dosimetric advantages, including D₂, CI and HI of PTV, as well as the maximum and mean doses of hippocampus and eyeballs, and the maximum doses of optic nerves and brainstem. The two Halcyon plans significantly reduced the delivery time and showed the higher gamma passing rate than the three plans of C-arm accelerators.

Conclusions: Compared with the C-arm accelerators, the dose of hippocampus and the delivery times on Halcyon are relatively significantly reduced for hippocampal-sparing PCI. Three arcs are recommended for VMAT plans with the Halcyon in hippocampal-sparing PCI.

Keywords: Halcyon; Trilogy; TrueBeam; hippocampalsparing; prophylactic cranial irradiation; small cell lung cancer; volumetric modulated arc therapy.

Grants and funding

This study was supported by the National Natural Science Foundation of China (Grant No. 82072094), the Natural Science Foundation of Shandong Province (Grant No. ZR2019LZL017 and No. ZR2020QH198), the Taishan Scholars Project of Shandong Province (Grant No. ts201712098), the Natural Science Foundation of Henan Province (Grant No. 222300420575).