Computational Methods to Predict Intrinsically Disordered Regions and Functional Regions in Them

Abstract

Intrinsically disordered regions (IDRs) are protein regions that do not adopt fixed tertiary structures. Since these regions lack ordered three-dimensional structures, they should be excluded from the target portions of homology modeling. IDRs can be predicted from the amino acid sequences, because their amino acid compositions are different from that of the structured domains. This chapter provides a review of the prediction methods of IDRs and a case study of IDR prediction.

Keywords: Amino acid sequences; Bioinformatics; Intrinsically disordered protein; Machine learning; Molecular recognition features; Protean segments; Short linear motif.