Palmitate paves the way to lung metastasis

Alina M Winkelkotte; Almut Schulze

doi:10.1016/j.trecan.2023.03.001

Palmitate paves the way to lung metastasis

Trends Cancer. 2023 May;9(5):376-378. doi: 10.1016/j.trecan.2023.03.001. Epub 2023 Mar 21.

Authors

Alina M Winkelkotte¹, Almut Schulze²

Affiliations

¹ Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.
² Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address: almut.schulze@dkfz-heidelberg.de.

PMID: 36959035
DOI: 10.1016/j.trecan.2023.03.001

Abstract

New findings by Altea-Manzano et al. demonstrate that primary breast tumours or a high-fat diet induce palmitate secretion by alveolar type 2 (AT2) cells to prepare a premetastatic niche that promotes lung metastasis. Palmitate is utilised by cancer cells via carnitine palmitoyltransferase 1a (CPT1a) and lysine acetyltransferase 2a (KAT2a) to acetylate nuclear factor-κB (NF-κB)/p65. Blocking these enzymes reduced metastasis formation in both lean and high-fat diet mice.

Keywords: NF-kB; breast cancer; lung metastasis; palmitate; premetastatic niche; protein acetylation.

MeSH terms

Animals
Lung Neoplasms* / genetics
Mice
NF-kappa B
Palmitates* / pharmacology

Substances

Palmitates
NF-kappa B