Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension

Binghao Ma; Yuanyuan Cao; Jia Qin; Zhuo Chen; Gaoyun Hu; Qianbin Li

doi:10.1016/j.drudis.2023.103559

Pulmonary artery smooth muscle cell phenotypic switching: A key event in the early stage of pulmonary artery hypertension

Drug Discov Today. 2023 May;28(5):103559. doi: 10.1016/j.drudis.2023.103559. Epub 2023 Mar 22.

Authors

Binghao Ma¹, Yuanyuan Cao¹, Jia Qin¹, Zhuo Chen¹, Gaoyun Hu¹, Qianbin Li²

Affiliations

¹ Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, China; Hunan Key Laboratory of Small Molecules for Diagnosis and Treatment of Chronic Disease, Changsha 410013, Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Changsha 410013, Hunan, China.
² Department of Medicinal Chemistry, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, China; Hunan Key Laboratory of Small Molecules for Diagnosis and Treatment of Chronic Disease, Changsha 410013, Hunan, China; Hunan Key Laboratory of Organ Fibrosis, Changsha 410013, Hunan, China. Electronic address: qbli@csu.edu.cn.

PMID: 36958640
DOI: 10.1016/j.drudis.2023.103559

Abstract

Pulmonary arterial hypertension (PAH) is a currently incurable pulmonary vascular disease. Since current research on PAH is mainly aimed at the middle and late stages of disease progression, no satisfactory results have been achieved. This has led researchers to focus on the early stages of PAH. This review highlights for the first time a key event in the early stages of PAH progression, namely, the occurrence of pulmonary arterial smooth muscle cell (PASMC) phenotypic switching. Summarizing the related reports of phenotypic switching provides new perspectives and directions for the early pathological progression and treatment strategies for PAH.

Keywords: early stage; phenotypic switching; pulmonary arterial hypertension; pulmonary smooth muscle cells; signaling pathways; small molecular regulators.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation / physiology
Humans
Hypertension, Pulmonary* / drug therapy
Myocytes, Smooth Muscle / pathology
Pulmonary Arterial Hypertension* / pathology
Pulmonary Artery / pathology
Signal Transduction / physiology