Quantification of scleral changes during dynamic accommodation

Iulen Cabeza-Gil; Fabrice Manns; Begoña Calvo; Marco Ruggeri

doi:10.1016/j.exer.2023.109441

Quantification of scleral changes during dynamic accommodation

Exp Eye Res. 2023 May:230:109441. doi: 10.1016/j.exer.2023.109441. Epub 2023 Mar 22.

Authors

Iulen Cabeza-Gil¹, Fabrice Manns², Begoña Calvo³, Marco Ruggeri⁴

Affiliations

¹ Aragón Institute of Engineering Research (i3A), University of Zaragoza, Spain. Electronic address: iulen@unizar.es.
² Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA.
³ Aragón Institute of Engineering Research (i3A), University of Zaragoza, Spain; Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER-BBN), Zaragoza, Spain.
⁴ Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, FL, USA. Electronic address: MRuggeri@med.miami.edu.

PMID: 36958428
DOI: 10.1016/j.exer.2023.109441

Abstract

The mechanics of accommodation is a complex process that involves multiple intraocular ocular structures. Recent studies suggest that there is deformation of the sclera during accommodation that may also play a role in accommodation, influencing ciliary muscle contraction and contributing to the accommodative response. However, the type and magnitude of the deformations measured varies significantly across studies. We present high-resolution synchronous OCT measurements of the anterior sclera contour and thickness and lens thickness acquired in real-time during accommodative responses to 4D step stimuli. The lens thickness was used as an assessment of objective accommodation. No changes in nasal and temporal anterior scleral contour and scleral thickness were found during accommodation within the precision of our measurements. Our results demonstrate that there are no significant scleral deformations during accommodation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Accommodation, Ocular
Ciliary Body
Lens, Crystalline* / physiology
Sclera
Tomography, Optical Coherence / methods

Grants and funding

R01 EY014225/EY/NEI NIH HHS/United States