To assess dynamics of SARS-CoV-2 in Greater Accra Region, Ghana, we analyzed SARS-CoV-2 genomic sequences from persons in the community and returning from international travel. The Accra Metropolitan District was a major origin of virus spread to other districts and should be a primary focus for interventions against future infectious disease outbreaks.
Keywords: 2019 novel coronavirus disease; Accra Metropolitan District; COVID-19; Ghana; Greater Accra Region; SARS-CoV-2; coronavirus disease; genomic surveillance; respiratory infections; severe acute respiratory syndrome coronavirus 2; variants; viruses; zoonoses.