Doxycycline Postexposure Prophylaxis Could Induce Cross-Resistance to Other Classes of Antimicrobials in Neisseria gonorrhoeae : An In Silico Analysis

Thibaut Vanbaelen; Sheeba Santhini Manoharan-Basil; Chris Kenyon

doi:10.1097/OLQ.0000000000001810

Doxycycline Postexposure Prophylaxis Could Induce Cross-Resistance to Other Classes of Antimicrobials in Neisseria gonorrhoeae : An In Silico Analysis

Sex Transm Dis. 2023 Aug 1;50(8):490-493. doi: 10.1097/OLQ.0000000000001810. Epub 2023 Mar 23.

Authors

Thibaut Vanbaelen¹, Sheeba Santhini Manoharan-Basil¹, Chris Kenyon

Affiliation

¹ From the STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

PMID: 36952471
DOI: 10.1097/OLQ.0000000000001810

Abstract

We found that tetracycline resistance-associated mutations and genes in Neisseria gonorrhoeae are linked to mutations causing resistance to other antimicrobials. Therefore, the use of doxycycline postexposure prophylaxis may select for resistance to other antimicrobials.

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Anti-Infective Agents* / pharmacology
Doxycycline / pharmacology
Doxycycline / therapeutic use
Drug Resistance, Bacterial / genetics
Gonorrhea* / drug therapy
Gonorrhea* / prevention & control
Humans
Microbial Sensitivity Tests
Neisseria gonorrhoeae / genetics
Tetracycline / pharmacology

Substances

Anti-Bacterial Agents
Doxycycline
Anti-Infective Agents
Tetracycline