High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Elodie Bousquet; Camille Chenevier-Gobeaux; Thara Jaworski; Héloïse Torres-Villaros; Marta Zola; Irmela Mantel; Laura Kowalczuk; Alexandre Matet; Alejandra Daruich; Min Zhao; Suzanne Yzer; Francine Behar-Cohen

doi:10.1016/j.xops.2023.100278

High Levels of C-Reactive Protein with Low Levels of Pentraxin 3 as Biomarkers for Central Serous Chorioretinopathy

Ophthalmol Sci. 2023 Feb 3;3(3):100278. doi: 10.1016/j.xops.2023.100278. eCollection 2023 Sep.

Authors

Elodie Bousquet^{1

2}, Camille Chenevier-Gobeaux³, Thara Jaworski², Héloïse Torres-Villaros¹, Marta Zola^{1

2}, Irmela Mantel⁴, Laura Kowalczuk⁴, Alexandre Matet⁵, Alejandra Daruich^{2

6}, Min Zhao², Suzanne Yzer⁷, Francine Behar-Cohen^{1

2}

Affiliations

¹ Department of Ophthalmology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France.
² Centre de Recherche des Cordeliers, INSERM, University of Paris Cité, Physiopathology of ocular diseases: Therapeutic innovations, Paris, France.
³ Service de diagnostic biologique automatisé, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France.
⁴ Department of Ophthalmology, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, University of Lausanne, Switzerland.
⁵ Department of Ophthalmology, Institut Curie, University of Paris Cité, Paris, France.
⁶ Department of Ophthalmology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris Cité, Paris, France.
⁷ Department of Ophthalmology, Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Abstract

Purpose: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.

Design: Cross-sectional multicenter study.

Participants: Patients with CSCR compared with age- and sex-matched healthy participants.

Methods: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.

Main outcome measures: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.

Results: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.

Conclusions: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.

Financial disclosures: The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Keywords: AMD, age-related macular degeneration; C-reactive protein; CRP, C-reactive protein; CSCR, central serous chorioretinopathy; Central serous chorioretinopathy; FH, factor H; Glucocorticoid; HPA, hypothalamic-pituitary-adrenal; IL, interleukin; Inflammation, Pentraxin 3; PTX, pentraxin.