Osteoporosis: Review of Etiology, Mechanisms, and Approach to Management in the Aging Population

Sonali Khandelwal; Nancy E Lane

doi:10.1016/j.ecl.2022.10.009

Osteoporosis: Review of Etiology, Mechanisms, and Approach to Management in the Aging Population

Endocrinol Metab Clin North Am. 2023 Jun;52(2):259-275. doi: 10.1016/j.ecl.2022.10.009. Epub 2023 Feb 19.

Authors

Sonali Khandelwal¹, Nancy E Lane²

Affiliations

¹ Rush University Medical Center, 1611 West Harrison Suite 510, Chicago, IL 60612, USA. Electronic address: sonali_khandelwal@rush.edu.
² University of California at Davis School of Medicine.

PMID: 36948779
DOI: 10.1016/j.ecl.2022.10.009

Abstract

Osteoporosis is the most common metabolic bone disease. With special respect to the aging population, it is very common, not only due to changes in lifestyle and diet but as a result of the aging process there is low-grade inflammation and immune system activation that directly affects bone strength and quality. This article provides a review of the incidence, etiology, and approach to screening and management of osteoporosis in the aging population. A thorough screening of lifestyle, environmental, and clinical conditions will be reviewed which identifies appropriate candidates for screening and treatment.

Keywords: Aging and bone loss; Bone loss; Fracture risk and aging; Osteoporosis.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Aged
Aging / physiology
Bone Density* / physiology
Bone and Bones
Humans
Incidence
Osteoporosis* / diagnosis
Osteoporosis* / epidemiology
Osteoporosis* / etiology