Increased gestational palmitic acid predisposes offspring to congenital heart disease

Yang Lv; Ri-Feng Gao; Chen-Xi Yang; Ying-Jia Xu; Yi-Qing Yang

doi:10.1016/j.xcrm.2023.100984

Increased gestational palmitic acid predisposes offspring to congenital heart disease

Cell Rep Med. 2023 Mar 21;4(3):100984. doi: 10.1016/j.xcrm.2023.100984.

Authors

Yang Lv¹, Ri-Feng Gao¹, Chen-Xi Yang¹, Ying-Jia Xu², Yi-Qing Yang³

Affiliations

¹ Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
² Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. Electronic address: xiyingjia@5thhospital.com.
³ Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Cardiovascular Research Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. Electronic address: yangyiqing@fudan.edu.cn.

Abstract

Identification of the causes for congenital heart disease (CHD) is a prerequisite for precise prevention and personalized treatment of CHD. Zhao et al.¹ show increased that gestational serum palmitic acid (PA) predisposes offspring to CHD by perturbating the MARS/K-Hcy/GATA4 signaling pathway.

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MeSH terms

Case-Control Studies
Heart Defects, Congenital* / etiology
Humans
Palmitic Acid*

Substances

Palmitic Acid