Au (III) cross-linked hollow organosilica capsules from 3-aminopropyltriethoxysilane

Jingwen Ba; Yandong Han; Lin Zhang; Wensheng Yang

doi:10.1016/j.jcis.2023.03.047

Au (III) cross-linked hollow organosilica capsules from 3-aminopropyltriethoxysilane

J Colloid Interface Sci. 2023 Jul:641:428-436. doi: 10.1016/j.jcis.2023.03.047. Epub 2023 Mar 11.

Authors

Jingwen Ba¹, Yandong Han¹, Lin Zhang¹, Wensheng Yang²

Affiliations

¹ Engineering Research Center for Nanomaterials, Henan University, Zhengzhou 450000, China.
² Engineering Research Center for Nanomaterials, Henan University, Zhengzhou 450000, China; State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: wsyang@jlu.edu.cn.

PMID: 36948098
DOI: 10.1016/j.jcis.2023.03.047

Abstract

Hollow organosilica capsules have received extensive interest due to their application potentials in catalyst, sensor, drug delivery etc. In this work, we demonstrate a novel strategy to fabricate hollow organosilica capsules based on coordination interaction, by using 3-aminopropyltriethoxysilane (APTES) as precursor and Au (III) as cross-linker. In this approach, stable APTES droplets are first formed in water with the presence of Au (III) due to the coordination effect between Au (III) and the amino groups of APTES located on the surface of the droplets. Subsequently, the self-catalyzed hydrolysis/condensation of APTES allows for the formation of hollow organosilica capsules, in which the droplets of APTES themselves act as soft template and the Au (III) as cross-linker. The formation mechanism of the capsules was investigated, and potential of the as-prepared Au (III) cross-linked hollow organosilica capsules as glutathione (GSH) sensitive drug carriers was evaluated. In addition, Au particle embedded hollow capsules are further obtained by in-situ reduction of the Au (III) in the shell, which showed excellent stability towards the cyclic catalytic reductions of p-nitroaniline.

Keywords: Au particles; Biodegradation; Chlorauric acid; Coordination; Hollow organosilica capsules.