With the increasing signal rates of a long-haul backbone dense-wavelength-division-multiplexing (DWDM) transmission system, e.g., from 100 Gb/s to 400 Gb/s and even to 800 Gb/s, optical path impairments simultaneously become more severe. Harmful factors being formerly insignificant become noticeable, e.g., nonlinear phase noise (NPN) on main DWDM channels induced by the cross-phase modulation (XPM) from the low-speed optical supervisory channel (OSC). Field trials show that a greater than 5.13-dB penalty can be observed on the shortest channel of 400G DP-16QAM-PCS over G.654.E links, which greatly degrades the overall transmission performance and limits the maximum reach. In this paper, we propose a dual-OSC structure with opposite signals to compensate for performance degradation caused by OSC-induced NPN. This method involves no extra digital signal processing (DSP), which is not only simple but also applicable for universal signal rates. By experimental demonstration, a 1.32-dB gain in Q (dB) for 200G DP-16QAM transmission over 1618-km G.652.D can be done, almost achieving the same performance as the no OSC case.