Antidepressant Effects of Psilocybin in the Absence of Psychedelic Effects

Joshua D Rosenblat; Marisa Leon-Carlyle; Shaun Ali; M Ishrat Husain; Roger S McIntyre

doi:10.1176/appi.ajp.20220835

Antidepressant Effects of Psilocybin in the Absence of Psychedelic Effects

Am J Psychiatry. 2023 May 1;180(5):395-396. doi: 10.1176/appi.ajp.20220835. Epub 2023 Mar 22.

Authors

Joshua D Rosenblat, Marisa Leon-Carlyle, Shaun Ali, M Ishrat Husain, Roger S McIntyre¹

Affiliation

¹ Department of Psychiatry, University of Toronto, Toronto (Rosenblat, Leon-Carlyle, Husain, McIntyre); Braxia Health, Canadian Centre for Rapid Treatment Excellence, Mississauga, Ont., Canada (Rosenblat, Leon-Carlyle, Ali, McIntyre); Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto (Husain); Brain and Cognition Discovery Foundation (BCDF), Toronto (McIntyre).

PMID: 36945824
DOI: 10.1176/appi.ajp.20220835

No abstract available

Keywords: 5HT2A; Depression; Depressive Disorders; Mood Disorder; Psilocybin; Psychedelic; Psychopharmacology; Psychotherapy; Psychotomimetic; Tryptamine.

Publication types

Letter

MeSH terms

Antidepressive Agents / pharmacology
Antidepressive Agents / therapeutic use
Hallucinogens* / pharmacology
Hallucinogens* / therapeutic use
Humans
Lysergic Acid Diethylamide
Psilocybin / pharmacology
Psilocybin / therapeutic use

Substances

Hallucinogens
Psilocybin
Lysergic Acid Diethylamide
Antidepressive Agents