Clinical features and Surgical Outcome of Clear Cell Papillary Renal Cell Tumor: result from a prospective cohort

Si Hyun Kim; Jang Hee Han; Seung-Hwan Jeong; Hyeong Dong Yuk; Ja Hyeon Ku; Cheol Kwak; Hyeon Hoe Kim; Kyung Chul Moon; Chang Wook Jeong

doi:10.1186/s12894-023-01216-7

Clinical features and Surgical Outcome of Clear Cell Papillary Renal Cell Tumor: result from a prospective cohort

BMC Urol. 2023 Mar 21;23(1):41. doi: 10.1186/s12894-023-01216-7.

Authors

Si Hyun Kim^{1

2}, Jang Hee Han^{1

3}, Seung-Hwan Jeong^{1

3}, Hyeong Dong Yuk^{1

3}, Ja Hyeon Ku^{1

3}, Cheol Kwak^{1

3}, Hyeon Hoe Kim^{1

3}, Kyung Chul Moon⁴, Chang Wook Jeong⁵

Affiliations

¹ Department of Urology, Seoul National University Hospital, Seoul, Korea.
² Department of Urology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
³ Department of Urology, Seoul National University College of medicine, Seoul, Korea.
⁴ Department of Pathology, Seoul National University Hospital, Seoul national University College of medicine, Seoul, Korea.
⁵ Department of Urology, Seoul National University Hospital, Seoul national University College of medicine, 101 Daehak-ro, Joungno-gu, Seoul, 03080, Korea. drboss@snu.ac.kr.

Abstract

Background: Clear cell papillary renal cell tumor (CCPRCT) was first reported in 2006 a patient with end stage renal disease. After that it was discovered in the kidney without end stage renal disease in the 2010s and started to be mentioned in pathology and urology. The incidence of CCPRCT is low and most of it is discovered incidentally, so there is a lack of reports on clinical characteristics and surgical outcome.

Methods: This study used clinical data from the Seoul National University Prospectively Enrolled Registry for Renal Cell Carcinoma-Nephrectomy (SUPER-RCC-Nx). Between August 2016 and July 2022, patients who underwent radical or partial nephrectomy with clear cell papillary RCC with pathological finding were included in this study. All patients' pathologic reports were reviewed by 1 pathologist. Clinical characteristics and surgical outcomes were presented through descriptive statistics, and Kaplan-Meier curve used for survival analysis.

Results: Of the 2057 patients, CCPRCT was reported in 36 patients (1.8%). The median follow up period was 26.8 months. The median age was 67 years, and there were 10 females and 26 males. The median tumor size was 1.2 cm. Twenty-nine patients underwent partial nephrectomy. Seven patients with end-stage renal disease underwent radical nephrectomy. The median operative time for patients who underwent partial nephrectomy was 97.5 min and the estimated blood loss was 100 cc. The median hospital days was 4 and 30-day complications were 2 cases with clavien-dindo classification III or higher. During the follow-up period, there was no recurrence and cancer specific mortality.

Conclusions: The size of CCPRCT was small and there was no advanced stage at that time of diagnosis. There was no recurrence or cancer specific mortality during the follow-up period. A multi-center study with a large scale is needed in the future.

Trial registration: Seoul National University Hospital (SNUH) Institutional Review Board (IRB) (approval number: 2210-126-1371).

Keywords: Nephrectomy; Pathology; Renal cell carcinoma; Small renal mass; Surgical.

Publication types

Multicenter Study

MeSH terms

Aged
Carcinoma, Renal Cell* / pathology
Female
Humans
Kidney Failure, Chronic* / surgery
Kidney Neoplasms* / pathology
Male
Nephrectomy
Prospective Studies
Retrospective Studies
Treatment Outcome