Promising gas therapies for severe COVID-19

Ting Wang; Qian Xiang; Jinjun Bian

doi:10.1016/j.jointm.2021.05.001

Promising gas therapies for severe COVID-19

J Intensive Med. 2021 May 27;1(2):99-102. doi: 10.1016/j.jointm.2021.05.001. eCollection 2021 Oct.

Authors

Ting Wang¹, Qian Xiang¹, Jinjun Bian¹

Affiliation

¹ Department of Anesthesiology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.

Abstract

The novel coronavirus disease 2019 (COVID-19) pandemic is a worldwide catastrophe, thoroughly challenging the healthcare systems. A growing number of victims suffer from a remarkable acute respiratory distress syndrome (ARDS) that necessitates admission to the intensive care unit (ICU), but there are no satisfactory treatments. Various gas therapies including nitric oxide, ozone, hyperbaric oxygen, hydrogen, and heliox have been employed in the fight against the pandemic and have improved clinical outcomes. However, the potential roles of these gases in COVID-19 treatment need to be verified in well-designed randomized controlled trials. This paper reviews advances in gaseous therapy of COVID-19.

Keywords: Gas therapy; Hyperbaric oxygen; Nitric oxide; Ozone; coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Publication types

Review