Prostate cancer radiotherapy and incidental testicular irradiation: Impact on gonadal function

Jennifer Le Guevelou; Thomas Zilli

doi:10.1016/j.ctro.2023.100611

Prostate cancer radiotherapy and incidental testicular irradiation: Impact on gonadal function

Clin Transl Radiat Oncol. 2023 Mar 8:40:100611. doi: 10.1016/j.ctro.2023.100611. eCollection 2023 May.

Authors

Jennifer Le Guevelou^{1

2}, Thomas Zilli^{2

3

4}

Affiliations

¹ Radiation Oncology, Centre Eugène Marquis, Rennes, France.
² Faculty of Medicine, University of Geneva, Geneva, Switzerland.
³ Radiation Oncology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.
⁴ Università della Svizzera Italiana, Lugano, Switzerland.

Abstract

Incidental testicular irradiation during prostate cancer radiotherapy is rarely documented in literature and the long-term impact on gonadal function largely underreported. Here we present an overview of available data on incidental testicular irradiation and radiation-induced hypogonadism during prostate cancer radiotherapy and discuss future technical developments to minimize testis irradiation.

Keywords: Hypogonadism; Prostate cancer; Radiotherapy; Sexual toxicity; Testicles; Testosterone levels.