Scurvy, abnormal MRI, and gelatinous bone marrow in an adolescent with avoidant restrictive food intake disorder

Ginny Claire Kim; Asha M Davidson; Rebecca M Beyda; Mona A Eissa

doi:10.1186/s40337-023-00770-7

Scurvy, abnormal MRI, and gelatinous bone marrow in an adolescent with avoidant restrictive food intake disorder

J Eat Disord. 2023 Mar 20;11(1):41. doi: 10.1186/s40337-023-00770-7.

Authors

Ginny Claire Kim¹, Asha M Davidson², Rebecca M Beyda², Mona A Eissa²

Affiliations

¹ University of Texas Health Science Center, 6431 Fannin, MSB 3.150, Houston, TX, 77030, USA. claire.kim2@gmail.com.
² University of Texas Health Science Center, 6431 Fannin, MSB 3.150, Houston, TX, 77030, USA.

Abstract

Background: Although medical literature describes pediatric scurvy as "rare", a growing number of case reports suggests otherwise. Patients often undergo costly and unnecessary workup due to unfamiliarity with the presentation of scurvy. This case report further supports the small yet growing literature documenting scurvy and its manifestations in patients with eating disorders.

Case presentation: A 15-year-old female presented to the emergency department with bilateral knee and ankle swelling and pain in the setting of chronic lower limb rash and BMI of 16.3. For years, she had restricted her diet to carbohydrates. Exam showed perifollicular petechial hemorrhagic rash with corkscrew hairs, knee edema, ankle edema with restricted range of motion, and antalgic gait. She was admitted for severe malnutrition from avoidant restrictive food intake disorder. Her hospital course was complicated by recurrent normocytic anemia and fever. Hematology workup revealed anemia from iron deficiency, vitamin K deficiency, and anemia of chronic disease. Rheumatology workup was negative. MRI findings showed dark T1 and bright T2 signals and were read as consistent with leukemia/lymphoma, chronic multifocal osteomyelitis, or Langerhans cell histiocytosis. However, bone marrow biopsy showed gelatinous transformation secondary to malnutrition. She was treated with vitamin C and a nutrition plan and her symptoms improved.

Conclusions: Although this patient had common manifestations of scurvy, including perifollicular petechial hemorrhagic rash, joint effusions, anemia, and recurrent fevers, she still underwent an extensive workup. Clinicians should be aware that scurvy can present with multiple symptoms that mimic infectious, rheumatic, oncologic and hematological disease. Clinicians should have a high index of suspicion for scurvy in patients with malnutrition and eating disorders.

Keywords: ARFID; Avoidant restrictive food intake disorder; GBM; Gelatinous transformation of bone marrow; Scurvy; Vitamin C deficiency.