[Immunotherapy in the context of other head and neck cancer treatment modalities-highlights of the ASCO and ESMO annual meeting 2022]

HNO. 2023 Jul;71(7):440-445. doi: 10.1007/s00106-023-01287-w. Epub 2023 Mar 20.
[Article in German]

Abstract

Immunotherapeutic agents are nowadays established for treatment of a wide variety of tumor entities, including squamous cell carcinoma of the head and neck region. Originally used in the palliative setting, these are increasingly administered with curative intent, e.g., as neoadjuvant treatment. Current research addresses the questions of which patients benefit from the treatment and which combination therapies are successful. The present article summarizes relevant findings of the two international cancer congresses in 2022.

Immuntherapeutische Agenzien haben mittlerweile einen festen Stellenwert in der Therapie verschiedenster Tumorentitäten inklusive der plattenepithelialen Kopf-Hals-Karzinome. Initial wurden sie im palliativen Setting eingesetzt, zunehmend aber auch in kurativer Intention, z. B. als Neoadjuvanz. In der heutigen Forschung geht es u. a. darum zu klären, welche Patienten von der Therapie profitieren und welche Kombinationstherapien erfolgreich sind. Im vorliegenden Artikel werden die relevanten Erkenntnisse der beiden internationalen Krebskongresse 2022 zusammengefasst.

Keywords: Chemoradiotherapy; Combined modality therapy; Immune checkpoint inhibitors; Neoadjuvant therapy; Squamous cell carcinoma of head and neck.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Carcinoma, Squamous Cell* / therapy
  • Combined Modality Therapy
  • Head and Neck Neoplasms* / drug therapy
  • Humans
  • Immunologic Factors / therapeutic use
  • Immunotherapy

Substances

  • Immunologic Factors