Large eddy simulation of droplet transport and deposition in the human respiratory tract to evaluate inhalation risk

PLoS Comput Biol. 2023 Mar 20;19(3):e1010972. doi: 10.1371/journal.pcbi.1010972. eCollection 2023 Mar.

Abstract

As evidenced by the worldwide pandemic, respiratory infectious diseases and their airborne transmission must be studied to safeguard public health. This study focuses on the emission and transport of speech-generated droplets, which can pose risk of infection depending on the loudness of the speech, its duration and the initial angle of exhalation. We have numerically investigated the transport of these droplets into the human respiratory tract by way of a natural breathing cycle in order to predict the infection probability of three strains of SARS-CoV-2 on a person who is listening at a one-meter distance. Numerical methods were used to set the boundary conditions of the speaking and breathing models and large eddy simulation (LES) was used for the unsteady simulation of approximately 10 breathing cycles. Four different mouth angles when speaking were contrasted to evaluate real conditions of human communication and the possibility of infection. Breathed virions were counted using two different approaches: the breathing zone of influence and direction deposition on the tissue. Our results show that infection probability drastically changes based on the mouth angle and the breathing zone of influence overpredicts the inhalation risk in all cases. We conclude that to portray real conditions, the probability of infection should be based on direct tissue deposition results to avoid overprediction and that several mouth angles must be considered in future analyses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • COVID-19*
  • Humans
  • Respiration
  • Respiratory System
  • SARS-CoV-2*

Grants and funding

This research was partially supported by JST CREST “Creation of fundamental technologies by interdisciplinary research to coexist with infectious diseases including COVID-19” (Issue name: Development of the integrated risk assessment system for the viral droplet infection on a supercomputer and its social implementation), Grant Number JPMJCR20H7, Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.