Decline in intravenous immunoglobulin titer against influenza virus A/H2N2 derived from donors in Japan

Mikihiro Yunoki; Ritsuko Kubota-Koketsu; Tatsuo Shioda

doi:10.1002/jmv.28685

Decline in intravenous immunoglobulin titer against influenza virus A/H2N2 derived from donors in Japan

J Med Virol. 2023 Mar;95(3):e28685. doi: 10.1002/jmv.28685.

Authors

Mikihiro Yunoki¹, Ritsuko Kubota-Koketsu², Tatsuo Shioda²

Affiliations

¹ R&D Division, Japan Blood Products Organization, Tokyo, Japan.
² Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

PMID: 36939012
DOI: 10.1002/jmv.28685

Abstract

Human influenza A/H2N2 can induce a pandemic in the future. This study evaluated the hemagglutination inhibition and neutralizing titers of intravenous immunoglobulin against A/H2N2 viruses, indicating the status of the donor population. In this study, the antibody titers decreased during the study period-2012-2021-suggesting a reduction in the immunity of the studied population.

Keywords: hemagglutination inhibition; human influenza A/H2N2; human intravenous immunoglobulin; influenza; intravenous immunoglobulin (IVIG); neutralization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alphainfluenzavirus*
Antibodies, Viral
Hemagglutination Inhibition Tests
Humans
Immunoglobulins, Intravenous / therapeutic use
Influenza A Virus, H2N2 Subtype
Influenza, Human* / epidemiology
Japan

Substances

Immunoglobulins, Intravenous
Antibodies, Viral