A new biphenyl from the stem bark of Garcinia macrantha A.C.Sm

Rifaldi; Edwin R Sukandar; Arif Fadlan; Sri Fatmawati; Adi S Purnomo; Johanis Wairata; Taslim Ersam

doi:10.1080/14786419.2023.2190113

A new biphenyl from the stem bark of Garcinia macrantha A.C.Sm

Nat Prod Res. 2023 Mar 20:1-6. doi: 10.1080/14786419.2023.2190113. Online ahead of print.

Authors

Rifaldi¹, Edwin R Sukandar¹, Arif Fadlan¹, Sri Fatmawati¹, Adi S Purnomo¹, Johanis Wairata², Taslim Ersam¹

Affiliations

¹ Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia.
² Department of Agrotechnology, Faculty of Natural Science and Engineering Technology, University of Halmahera, Tobelo, North Halmahera, Indonesia.

PMID: 36938907
DOI: 10.1080/14786419.2023.2190113

Abstract

In our continuation of exploring antidiabetic agents from Garcinia species, we found that the methanolic extract of G. macrantha A.C.Sm. exhibited considerable α-glucosidase inhibition of 58.20 ± 0.37% in sucrose substrate and 39.86 ± 2.07% in maltose substrate at 100 μg/mL. Phytochemical investigation on the extract revealed the presence of a new biphenyl, macrabiphenyl A, which was successfully elucidated by means of spectroscopic methods (HRESIMS and 1D and 2D NMR). The α-glucosidase inhibitory evaluation indicated that the new compound was weakly active against the enzyme.

Keywords: Clusiaceae; Garcinia macrantha A.C.Sm.; antidiabetic; antioxidant; biphenyl.