Efficient hemorrhage control of severe wound injuries is an urgent medical need, deserving agents with promising blood coagulation and biocompatible characteristics. Current work developed polydopamine (PDA) functionalized porous starch powder (PS-PDA) for emergency bleeding treatment. The micro-morphology and elements, chemical groups, and porosity of PS-PDA were systematically characterized. Its comparison with porous starch (PS) revealed the promising potential of this composite in medical practice. On one hand, PS-PDA showed superior surface area and biomineralization affinity over PS, along with comparable hemo/cyto-compatibility. On the other hand, the photothermal effect of PDA under near Infrared (NIR) light paved the possibility to accelerate blood coagulation in situ. In vivo studies indicated PS-PDA can significantly reduce blood loss and improvement of hemostasis efficiency accompanied by NIR light exposure. These results suggest that this newly developed PS-PDA powder can serve as a promising hemostatic material for bleeding wound control.
Keywords: Hemostasis; biomineralization; photothermal effect; polydopamine; starch.
Polydopamine functionalized porous starch (PS-PDA) was developed for bleeding controlPS-PDA showed superior surface area and biomineralization affinity over PSWith assistance of NIR irradiation, PS-PDA can accelerate blood coagulationPS-PDA showed therapeutic potential for both soft and hard tissue bleeding wound.