The association between arterial stiffness and cancer occurrence: Data from Kailuan cohort study

Yinong Jiang; Aijun Xing; Tesfaldet Habtemariam Hidru; Jiatian Li; Xiaolei Yang; Shuohua Chen; Yun-Long Xia; Shouling Wu

doi:10.3389/fcvm.2023.1112047

The association between arterial stiffness and cancer occurrence: Data from Kailuan cohort study

Front Cardiovasc Med. 2023 Mar 1:10:1112047. doi: 10.3389/fcvm.2023.1112047. eCollection 2023.

Authors

Yinong Jiang¹, Aijun Xing², Tesfaldet Habtemariam Hidru¹, Jiatian Li¹, Xiaolei Yang¹, Shuohua Chen³, Yun-Long Xia¹, Shouling Wu²

Affiliations

¹ Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
² Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, Hebei, China.
³ Health Department of Kailuan Group, Tangshan, China.

Abstract

Background: This study aimed to investigate whether increased arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV) is associated with cancer.

Materials and methods: A total of 45,627 Chinese adults underwent a baPWV examination. The participants were followed up from 1st January 2012 to 31st December 2018. Cox proportional hazards model was used to assess the association between the baPWV values and cancer.

Results: During a total follow-up duration of 172,775.69 person-years, there were 553 new cases of cancer. The subjects in the highest baPWV group showed an increased risk of cancer when compared with the lowest baPWV group as confirmed by multivariate-adjusted hazard ratios (HR = 1.51, 95% CI = 1.14∼2.00) in the entire cohort. Compared with participants in the lowest baPWV group, the HRs (95% CI) for digestive cancer in the second and third groups were 1.55 (1.00∼2.40) and 1.99 (1.19∼3.33), respectively. The Kaplan-Meier analysis demonstrated a significant increase in cancer in participants with a baPWV ≥ 18 m/s (P < 0.001). Compared with the lowest baPWV group, the highest baPWV group showed an increased risk of cancer in men (HR = 1.72, 95% CI = 1.22∼2.43) and those < 60 years (HR = 1.75, 95% CI = 1.20∼2.55), respectively.

Conclusion: Increased arterial stiffness measured by baPWV is associated with cancer occurrence, especially digestive cancer occurrence.

Clinical trial registration: ClinicalTrials.gov, identifier ChiCTR-TNRC-11001489.

Keywords: arterial stiffness; brachial-ankle pulse wave velocity; cancer; malignancy; mortality.

Grants and funding

This work was supported by the National Natural Science Foundation of China (82070427 to YJ and 81900439 to XY), Chang Jiang Scholars Program (T2017124 to Y-LX), and Liao Ning Revitalization Talents (XLYC2002096 to Y-LX).