Association between thyroid cancer and cardiovascular disease: A meta-analysis

Wen-Hsuan Tsai; Yi-Hong Zeng; Chun-Chuan Lee; Ming-Nan Chien; Sung-Chen Liu; Kuo-Liong Chien; Shih-Ping Cheng; Po-Jung Tseng; Ming-Chieh Tsai

doi:10.3389/fcvm.2023.1075844

Association between thyroid cancer and cardiovascular disease: A meta-analysis

Front Cardiovasc Med. 2023 Mar 3:10:1075844. doi: 10.3389/fcvm.2023.1075844. eCollection 2023.

Authors

Wen-Hsuan Tsai¹, Yi-Hong Zeng^{1

2}, Chun-Chuan Lee^{1

2}, Ming-Nan Chien^{1

2}, Sung-Chen Liu^{1

2}, Kuo-Liong Chien³, Shih-Ping Cheng⁴, Po-Jung Tseng⁵, Ming-Chieh Tsai^{1

2

3}

Affiliations

¹ Division of Endocrinology and Metabolism, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
² Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
³ Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
⁴ Department of General Surgery, Mackay Memorial Hospital, Taipei, Taiwan.
⁵ Division of Cardiovascular Surgery, Department of Surgery, Hsin Chu Armed Force Hospital, Hsinchu, Taiwan.

Abstract

Objective: To determine the association between thyroid cancer and coronary artery disease, atrial fibrillation, cerebrovascular disease, and cardiovascular disease mortality.

Methods: The PubMed, Embase, and Cochrane Library databases were searched for eligible studies from inception to September 22, 2022. Keywords included "thyroid cancer", "atrial fibrillation", "coronary artery disease", "cerebrovascular disease", and "mortality". Primary outcomes included the incidence of coronary artery disease, cerebrovascular disease, atrial fibrillation, and cardiovascular disease mortality among patients with thyroid cancer. Secondary outcomes included cardiovascular disease events among those with thyroid cancer that received or did not receive radioactive iodine or lenvatinib. Estimates were pooled using fixed- and random-effects meta-analysis.

Results: A total of 771,220 patients who underwent thyroidectomy in 15 studies were included. Risk for cerebrovascular disease (risk ratio [RR] 1.15 [95% confidence interval (CI) 1.10-1.21]) and atrial fibrillation [RR 1.59 (95% CI: 1.45-1.73)] were significantly increased. Risk for coronary artery disease was significantly increased [RR 1.12 (95% CI: 1.08-1.17)] in the common effect model. Cardiovascular disease mortality associated with thyroid cancer was not significant [RR 0.93 (95% CI: 0.59-1.45)]. Radioactive iodine had a neutral effect on cardiovascular disease [RR 1.00 (95% CI: 0.87-1.16)], and there was no beneficial nor harmful effect among different RAI doses.

Conclusions: Thyroid cancer was significantly associated with a higher risk for cerebrovascular disease and atrial fibrillation; however, the hazard risk was not different between patients with and without radioactive iodine treatment. Thyroid cancer treatment should be individualized considering the potential harms and benefits to cardiovascular health.

Keywords: cardiovascular disease; radioactive iodine; thyroid cancer; thyroxine; tyrosine kinase inhibitors.

Grants and funding

This paper was supported by grants from the Ministry of Science and Technology (MOST 110-2314-B-195-004).