Self-assembling peptides as immunomodulatory biomaterials

Andrea Hernandez; Jeffrey D Hartgerink; Simon Young

doi:10.3389/fbioe.2023.1139782

Self-assembling peptides as immunomodulatory biomaterials

Front Bioeng Biotechnol. 2023 Mar 1:11:1139782. doi: 10.3389/fbioe.2023.1139782. eCollection 2023.

Authors

Andrea Hernandez¹, Jeffrey D Hartgerink², Simon Young¹

Affiliations

¹ Katz Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, United States.
² Department of Chemistry and Department of Bioengineering, Rice University, Houston, TX, United States.

Abstract

Self-assembling peptides are a type of biomaterial rapidly emerging in the fields of biomedicine and material sciences due to their promise in biocompatibility and effectiveness at controlled release. These self-assembling peptides can form diverse nanostructures in response to molecular interactions, making them versatile materials. Once assembled, the peptides can mimic biological functions and provide a combinatorial delivery of therapeutics such as cytokines and drugs. These self-assembling peptides are showing success in biomedical settings yet face unique challenges that must be addressed to be widely applied in the clinic. Herein, we describe self-assembling peptides' characteristics and current applications in immunomodulatory therapeutics.

Keywords: biomaterials; cancer; immunotherapy; localized delivery; self-assembling peptides (SAP).

Publication types

Review

Abstract

Publication types

Grants and funding