Recent advances in 2D material-based phototherapy

Yi Tan; Haider Mohammed Khan; Bilal Ahmed Sheikh; Huan Sun; Hui Zhang; Jie Chen; Dingming Huang; Xinmei Chen; Changchun Zhou; Jianxun Sun

doi:10.3389/fbioe.2023.1141631

Recent advances in 2D material-based phototherapy

Front Bioeng Biotechnol. 2023 Mar 3:11:1141631. doi: 10.3389/fbioe.2023.1141631. eCollection 2023.

Authors

Yi Tan^{1

2}, Haider Mohammed Khan³, Bilal Ahmed Sheikh³, Huan Sun⁴, Hui Zhang^{1

5}, Jie Chen^{1

6}, Dingming Huang^{1

2}, Xinmei Chen^{1

2}, Changchun Zhou⁴, Jianxun Sun^{1

2}

Affiliations

¹ State Key Laboratory of Oral disease, National Clinical Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
² Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
³ Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.
⁴ National Engineering Research Centre for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, China.
⁵ Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
⁶ Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, China.

Abstract

Phototherapy, which generally refers to photothermal therapy (PTT) and photodynamic therapy (PDT), has received significant attention over the past few years since it is non-invasive, has effective selectivity, and has few side effects. As a result, it has become a promising alternative to traditional clinical treatments. At present, two-dimensional materials (2D materials) have proven to be at the forefront of the development of advanced nanomaterials due to their ultrathin structures and fascinating optical properties. As a result, much work has been put into developing phototherapy platforms based on 2D materials. This review summarizes the current developments in 2D materials beyond graphene for phototherapy, focusing on the novel approaches of PTT and PDT. New methods are being developed to go above and beyond conventional treatment to fully use the potential of 2D materials. Additionally, the efficacy of cutting-edge phototherapy is assessed, and the existing difficulties and future prospects of 2D materials for phototherapy are covered.

Keywords: 2D materials; antibacterial therapy; cancer therapy; photodynamic therapy; photothermal therapy.

Publication types

Review

Grants and funding

This work was partially supported by the Project of Chengdu Science and Technology Bureau (2021-YF05-01619-SN and 2021-RC05-00022-CG), Sichuan University Panzhihua Science and Technology Cooperation Project (2021CDPZH-4), Science and Technology Project of Tibet Autonomous Region (XZ201901-GB-08 and XZ202202YD0013C), Sichuan Science and Technology Program (2022YFG0066), and the 1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC21026 and ZYGD21001).