Opportunities and challenges related to ferroptosis in glioma and neuroblastoma

Huizhong Chi; Boyan Li; Qingtong Wang; Zijie Gao; Bowen Feng; Hao Xue; Gang Li

doi:10.3389/fonc.2023.1065994

Opportunities and challenges related to ferroptosis in glioma and neuroblastoma

Front Oncol. 2023 Mar 2:13:1065994. doi: 10.3389/fonc.2023.1065994. eCollection 2023.

Authors

Huizhong Chi^{1

2}, Boyan Li^{1

2}, Qingtong Wang^{1

2}, Zijie Gao^{1

2}, Bowen Feng^{1

2}, Hao Xue^{1

2}, Gang Li^{1

2}

Affiliations

¹ Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong, China.
² Shandong Key Laboratory of Brain Function Remodeling, Jinan, Shandong, China.

Abstract

A newly identified form of cell death known as ferroptosis is characterized by the peroxidation of lipids in response to iron. Rapid progress in research on ferroptosis in glioma and neuroblastoma has promoted the exploitation of ferroptosis in related therapy. This manuscript provides a review of the findings on ferroptosis-related therapy in glioblastoma and neuroblastoma and outlines the mechanisms involved in ferroptosis in glioma and neuroblastoma. We summarize some recent data on traditional drugs, natural compounds and nanomedicines used as ferroptosis inducers in glioma and neuroblastoma, as well as some bioinformatic analyses of genes involved in ferroptosis. Moreover, we summarize some data on the associations of ferroptosis with the tumor immunotherapy and TMZ drug resistance. Finally, we discuss future directions for ferroptosis research in glioma and neuroblastoma and currently unresolved issues.

Keywords: GPX4; ferroptosis; glioblastoma; immune; neuroblastoma.

Publication types

Review

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (Nos. 82273195, 81874083, 82072776, 82273286, 82072775, and 82203419), Natural Science Foundation of Shandong Province of China (Nos. ZR2020QH174 and ZR2021LSW025), Jinan Science and Technology Bureau of Shandong Province (No. 2021GXRC029), Key Clinical Research Project of Clinical Research Center of Shandong University (No. 2020SDUCRCA011) and Taishan Pandeng Scholar Program of Shandong Province (No. tspd20210322).