Diagnostic Utility of TUNEL Staining for Degenerative Keratoacanthoma Requiring Pathologic Differentiation from Seborrheic Keratosis

Mari Nakanishi; Makoto Kondo; Koji Habe; Akinobu Hayashi; Keiichi Yamanaka

doi:10.1159/000529728

Diagnostic Utility of TUNEL Staining for Degenerative Keratoacanthoma Requiring Pathologic Differentiation from Seborrheic Keratosis

Case Rep Dermatol. 2023 Mar 16;15(1):62-66. doi: 10.1159/000529728. eCollection 2023 Jan-Dec.

Authors

Mari Nakanishi¹, Makoto Kondo¹, Koji Habe¹, Akinobu Hayashi², Keiichi Yamanaka¹

Affiliations

¹ Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Japan.
² Department of Oncologic Pathology, Mie University, Graduate School of Medicine, Tsu, Japan.

Abstract

Tumors developed in 2 old women presented with pathological findings similar to seborrheic keratosis, although the clinical feature of tumor showed typical keratoacanthoma. In addition to these two cases, we compared the pathological findings of a total of four cases, one case each of keratoacanthoma and seborrheic keratosis, which were clinically and histopathological typical. These two cases and the typical keratoacanthoma showed cell apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and infiltration of cytotoxic T cells. The keratoacanthoma in the decompensated stage may be histologically similar to seborrheic keratosis. TUNEL staining can help in the diagnosis of fading keratoacanthoma.

Keywords: Degenerative keratoacanthoma; Immunological staining; Keratoacanthoma; Seborrheic keratosis; Terminal deoxynucleotidyl transferase dUTP nick end labeling stain.

Publication types

Case Reports

Grants and funding

The authors did not receive any financial support for the present study.