CRELD2, endoplasmic reticulum stress, and human diseases

Qin Tang; Qinhui Liu; Yanping Li; Li Mo; Jinhan He

doi:10.3389/fendo.2023.1117414

CRELD2, endoplasmic reticulum stress, and human diseases

Front Endocrinol (Lausanne). 2023 Mar 2:14:1117414. doi: 10.3389/fendo.2023.1117414. eCollection 2023.

Authors

Qin Tang¹, Qinhui Liu¹, Yanping Li¹, Li Mo², Jinhan He¹

Affiliations

¹ Department of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
² Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Abstract

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. Recent studies suggest that CRELD2 is associated with cartilage/bone metabolism homeostasis and pathological conditions involving ER stress such as chronic liver diseases, cardiovascular diseases, kidney diseases, and cancer. Herein, we first summarize ER stress and then critically review recent advances in the knowledge of the characteristics and functions of CRELD2 in various human diseases. Furthermore, we highlight challenges and present future directions to elucidate the roles of CRELD2 in human health and disease.

Keywords: CRELD2; endoplasmic reticulum stress; human diseases; metabolism; unfolded protein response.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Adhesion Molecules* / metabolism
Endoplasmic Reticulum / metabolism
Endoplasmic Reticulum Stress
Epidermal Growth Factor / metabolism
Extracellular Matrix Proteins*
Humans

Substances

Cell Adhesion Molecules
Extracellular Matrix Proteins
Epidermal Growth Factor
CRELD2 protein, human

Grants and funding

This work was supported by the National Natural Science Foundation of China (82025007, 81930020, 82270923); Research Funding from Sichuan Province (2021YJ0458); Post-Doctoral Research Project, West China Hospital of Sichuan University (2020HXBH095); Project funded by China Postdoctoral Science Foundation (2022M710099).