A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis

Alexander Kusnik; Shifan Li; Elliot Graziano; Roula Katerji; Gopal Ramaraju

doi:10.14309/crj.0000000000001012

A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis

ACG Case Rep J. 2023 Mar 16;10(3):e01012. doi: 10.14309/crj.0000000000001012. eCollection 2023 Mar.

Authors

Alexander Kusnik¹, Shifan Li², Elliot Graziano³, Roula Katerji⁴, Gopal Ramaraju³

Affiliations

¹ Department of Internal Medicine, Unity Hospital, Rochester, NY.
² Department of Internal Medicine, University of Rochester Medical Center, Rochester, NY.
³ Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY.
⁴ Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.

Abstract

Hepatocellular adenoma is a benign liver tumor often diagnosed incidentally in women of reproductive age who are taking oral contraceptives. In this study, we present a unique case of an 18-year-old man with known familial adenomatous polyposis who presented with sepsis in the setting of a recent total proctocolectomy and was incidentally found to have multiple large hepatic lesions. A biopsy of a liver lesion confirmed the diagnosis of a beta-catenin-activated hepatic adenoma. To the best of our knowledge, this is the first known case of beta-catenin-activated hepatic adenoma in a patient with a known familial adenomatous polyposis mutation. Beta-catenin is one of the many subtypes of hepatocellular adenomas, which carries a high risk of malignant transformation.

Keywords: beta-catenin; familial adenomatous polyposis; hepatic adenoma.

Publication types

Case Reports