Current strategies of plasmonic nanoparticles assisted surface-enhanced Raman scattering toward biosensor studies

Yangyang Zhou; Yongkai Lu; Yawen Liu; Xiaojun Hu; Hongxia Chen

doi:10.1016/j.bios.2023.115231

Current strategies of plasmonic nanoparticles assisted surface-enhanced Raman scattering toward biosensor studies

Biosens Bioelectron. 2023 May 15:228:115231. doi: 10.1016/j.bios.2023.115231. Epub 2023 Mar 15.

Authors

Yangyang Zhou¹, Yongkai Lu², Yawen Liu¹, Xiaojun Hu², Hongxia Chen³

Affiliations

¹ School of Medicine, Shanghai University, Shanghai, 200444, PR China; School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China.
² School of Life Sciences, Shanghai University, Shanghai, 200444, PR China.
³ School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: hxchen@shu.edu.cn.

PMID: 36934607
DOI: 10.1016/j.bios.2023.115231

Abstract

With the progressive nanofabrication technology, plasmonic nanoparticles (PNPs) have been increasingly deployed in the field of biosensing. PNPs have favorable biocompatibility, conductivity, and tunable optical properties. In addition, the localized surface plasmon resonance (LSPR) of PNPs plays a vital role in surface-enhanced Raman scattering (SERS). PNPs-based SERS biosensing enables wide-ranging applications for sensitive detection and high spatial and temporal resolution imaging. Numerous reviews of PNPs in the field of SERS biosensing highlight the fabrication or applications in one or more fields. However, the specific strategies for the SERS biosensor construction had not been summarized systematically. Thus, this work offers a comprehensive overview of SERS enhancement strategies based on PNPs, with a focus on SERS label-free detection along with label detection sensing construction, as well as its challenges and future trends.

Keywords: Enhancement strategy; Hotspots; Label-free detection; Nanotags; Plasmonic nanoparticles; SERS.

Publication types

Review

MeSH terms

Biosensing Techniques* / methods
Metal Nanoparticles*
Spectrum Analysis, Raman / methods
Surface Plasmon Resonance