Molecular mechanisms of nucleolar DNA damage checkpoint response

Trends Cell Biol. 2023 May;33(5):361-364. doi: 10.1016/j.tcb.2023.02.003. Epub 2023 Mar 16.

Abstract

Ribosomal DNA (rDNA) is transcribed into RNA in the nucleolus and is often challenged by different stress conditions. However, the underlying mechanisms of nucleolar DNA damage response (DDR) pathways remain elusive. Here, we provide distinct perspectives on how nucleolar DDR checkpoint pathways are activated by different stresses or by liquid-liquid phase separation (LLPS).

Keywords: APE1; ATM; ATR; DNA damage response; LLPS; nucleolus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle Checkpoints
  • Cell Nucleolus* / metabolism
  • DNA Damage*
  • DNA, Ribosomal / genetics
  • DNA, Ribosomal / metabolism
  • Humans

Substances

  • DNA, Ribosomal