Anti-stokes luminescent organic nanoparticles for frequency upconversion biomedical imaging

Guobo Chen; Yuhao Li; Jinliang Liu; Gang Huang; Qiwei Tian

doi:10.1016/j.nano.2023.102668

Anti-stokes luminescent organic nanoparticles for frequency upconversion biomedical imaging

Nanomedicine. 2023 Jun:50:102668. doi: 10.1016/j.nano.2023.102668. Epub 2023 Mar 16.

Authors

Guobo Chen¹, Yuhao Li², Jinliang Liu³, Gang Huang⁴, Qiwei Tian⁵

Affiliations

¹ Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China; School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
² Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China; School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: yhli@usst.edu.cn.
³ School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
⁴ Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. Electronic address: huanggang@sumhs.edu.cn.
⁵ Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. Electronic address: tianqw@sumhs.edu.cn.

PMID: 36933757
DOI: 10.1016/j.nano.2023.102668

Abstract

Frequency upconversion optical imaging has attracted great attention due to its remarkable advantages over traditional down-conversion optical imaging. However, the development of frequency upconversion optical imaging is extremely limited. Herein, five derivatives with BODIPY structure (B1-B5) were developed to investigate its frequency upconversion luminescence (FUCL) performance by introducing electron-donating and electron-withdrawing groups. Except for the nitro group decorated derivative, the other derivatives have strong and stable FUCL around 520 nm under 635 nm light excitation. More importantly, B5 retains FUCL ability after self-assembly. When applied to FUCL imaging of cells, B5 nanoparticles can be enriched in the cytoplasm and show a good signal-to-noise ratio. Meanwhile, FUCL tumor imaging can be achieved after 1 h of injection. This study not only provides a potential agent for FUCL biomedical imaging but also develops a new strategy for designing FUCL agents that exhibit excellent performance.

Keywords: BODIPY; Frequency upconversion luminescence; Nanoprobe; Optical imaging; Structure-function relationship.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Luminescence
Nanoparticles* / chemistry
Neoplasms*