Individual and combined effects of amoxicillin and carbamazepine to the marine copepod Tigriopus fulvus

Environ Sci Pollut Res Int. 2023 May;30(22):61672-61681. doi: 10.1007/s11356-023-26498-0. Epub 2023 Mar 18.

Abstract

Pharmaceuticals can be considered a global threat to aquatic ecosystems due to their pseudo-persistence and their potential toxicity towards non-target species. Amoxicillin (AMX) and carbamazepine (CBZ) and their mixture (1:1) were investigated on the marine copepod Tigriopus fulvus (Fischer, 1860) considering both acute and chronic endpoints. While acute and chronic exposure did not directly affect survival, reproductive endpoints were affected like the mean egg hatching time that was significantly longer than the negative control for treatments with AMX (0.789 ± 0.079 μg/L), CBZ (8.88 ± 0.89 μg/L), and AMX and CMZ as a mixture (1.03 ± 0.10 μg/L and 0.941 ± 0.094 μg/L), in that order.

Keywords: Acute and chronic toxicity; Amoxicillin; Carbamazepine; Mixture; Tigriopus fulvus.

MeSH terms

  • Amoxicillin / toxicity
  • Animals
  • Carbamazepine / toxicity
  • Copepoda*
  • Ecosystem
  • Reproduction
  • Water Pollutants, Chemical* / toxicity

Substances

  • Amoxicillin
  • Carbamazepine
  • Water Pollutants, Chemical