Structurally diverse glycosides with α-glucosidase inhibitory properties from water extract of the leaves of Cyclocarya paliurus

Li-Ping Zhu; Si-Yang Fang; Xing-Chen Lu; Qing-Qing Wang; Jie Wang; Chang-Qian Fang; Xiao-Gai Zhang; Jian Zhang; Ke Pan; Zhi-Qi Yin

doi:10.1016/j.fitote.2023.105473

Structurally diverse glycosides with α-glucosidase inhibitory properties from water extract of the leaves of Cyclocarya paliurus

Fitoterapia. 2023 Jun:167:105473. doi: 10.1016/j.fitote.2023.105473. Epub 2023 Mar 15.

Authors

Li-Ping Zhu¹, Si-Yang Fang², Xing-Chen Lu², Qing-Qing Wang³, Jie Wang⁴, Chang-Qian Fang⁵, Xiao-Gai Zhang⁵, Jian Zhang⁶, Ke Pan⁷, Zhi-Qi Yin⁸

Affiliations

¹ Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; Department of Endocrinology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing 211200, PR China.
² Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, PR China.
³ Wanbangde Pharmaceutical Group Hangzhou Pharmaceutical Technology Co., Ltd, Hangzhou 310000, PR China.
⁴ Instrumental Analysis Center of CPU, China Pharmaceutical University, Nanjing 210009, PR China.
⁵ Department of Endocrinology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing 211200, PR China.
⁶ Department of Endocrinology, Nanjing Lishui District Hospital of Traditional Chinese Medicine, Nanjing 211200, PR China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, PR China. Electronic address: zhangjian@jsatcm.com.
⁷ Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: kpan@cpu.edu.cn.
⁸ Department of TCMs Pharmaceuticals & State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: cpu-yzq@cpu.edu.cn.

PMID: 36931529
DOI: 10.1016/j.fitote.2023.105473

Abstract

In this work we investigated the chemical constituents of water extract of the leaves of Cyclocarya paliurus. Two new megastigmane glycosides (3 and 8), three aliphatic alcohol glycosides (9-11), and two aromatic glycosides (12 and 13), along with fourteen known compounds were isolated, and their in vitro inhibitory activity against α-glucosidase was evaluated. Compounds 13 and 15-18 displayed inhibitory activity with IC₅₀ values varying from 27.05 to 96.58 μM, and the structure-activity relationship among isolated compounds was discussed.

Keywords: Cyclocarya paliurus; Hypoglycemic; Large polar components; Water extract; α-glucosidase inhibitors.

MeSH terms

Glycosides* / chemistry
Molecular Structure
Plant Extracts / chemistry
Plant Leaves / chemistry
Water / analysis
alpha-Glucosidases* / metabolism

Substances

Glycosides
alpha-Glucosidases
Plant Extracts
Water