SnapShot: Mitochondrial signaling

Taylor A Poor; Navdeep S Chandel

doi:10.1016/j.molcel.2023.01.008

SnapShot: Mitochondrial signaling

Mol Cell. 2023 Mar 16;83(6):1012-1012.e1. doi: 10.1016/j.molcel.2023.01.008.

Authors

Taylor A Poor¹, Navdeep S Chandel²

Affiliations

¹ Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
² Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: nav@northwestern.edu.

PMID: 36931250
DOI: 10.1016/j.molcel.2023.01.008

Abstract

Mitochondria have emerged as signaling organelles with roles beyond their well-established function in generating ATP and metabolites for macromolecule synthesis. Healthy mitochondria integrate various physiologic inputs and communicate signals that control cell function or fate as well as adaptation to stress. Dysregulation of these mitochondrial signaling networks are linked to pathology. Here we outline a few modes of signaling between the mitochondrion and the cytoplasm. To view this SnapShot, open or download the PDF.

MeSH terms

Acclimatization
Cytoplasm / metabolism
Mitochondria* / metabolism
Organelles / metabolism
Signal Transduction*