Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual-Acceptor Engineering for NIR-II Excited Photothermal Theranostics

Jiangao Li; Miaomiao Kang; Zhijun Zhang; Xue Li; Weilin Xu; Dong Wang; Xike Gao; Ben Zhong Tang

doi:10.1002/anie.202301617

Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual-Acceptor Engineering for NIR-II Excited Photothermal Theranostics

Angew Chem Int Ed Engl. 2023 May 8;62(20):e202301617. doi: 10.1002/anie.202301617. Epub 2023 Apr 12.

Authors

Jiangao Li^{1

2}, Miaomiao Kang², Zhijun Zhang², Xue Li², Weilin Xu², Dong Wang², Xike Gao¹, Ben Zhong Tang³

Affiliations

¹ Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
² China Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, P. R. China.
³ Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen City, Guangdong, 518172, P. R. China.

PMID: 36929068
DOI: 10.1002/anie.202301617

Abstract

Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single photothermal agent is an appealing yet significantly challenging task. Herein, a precise dual-acceptor engineering strategy is exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating the molar proportions of the two employed electron acceptor moieties featuring different electronic affinity and π-conjugation degrees, and making full use of the active intramolecular motion-induced photothermal effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, an extremely high extinction coefficient, and satisfactory photothermal conversion behavior. Consequently, the unprecedented performance of SP4 NPs on 1064 nm laser-excited photoacoustic imaging (PAI)-guided photothermal therapy (PTT) is demonstrated by the precise tumor diagnosis and complete tumor elimination.

Keywords: Dual-Acceptor Engineering; Intramolecular Motions; NIR-II Absorption; Photothermal Theranostics; Semiconducting Polymers.

Abstract

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