BACKGROUND This prospective study, from a single center in Poland, aimed to evaluate the correction of residual ametropia, or refractive errors, after corneal grafting using femtosecond laser-assisted in situ keratomileusis (Femto-LASIK) in 60 patients (96 eyes) who had previously undergone deep anterior lamellar keratoplasty (DALK) compared with that achieved in 60 patients (108 eyes) who underwent vision correction using Femto-LASIK alone. MATERIAL AND METHODS The study group included 60 patients (96 eyes) whose residual ametropia was corrected using the Femto-LASIK procedure after having previously undergone DALK. The comparison group consisted of 60 patients (108 eyes) who underwent vision correction with the Femto-LASIK procedure without previously having undergone DALK. Uncorrected vision acuity, best-corrected vision acuity, and intraocular pressure were measured for both groups before the procedures and at 3, 6, 12, and 24 months after the procedures. Corneal endothelial cell density was evaluated by non-contact specular microscopy before the procedures and at 6, 12, and 24 months after the procedures. RESULTS In the study group, within the 24-month observation period, no transplant rejection, transplant decompensation, or corneal ectasia were noted. Statistical analysis did not show any significant differences between the best-corrected vision acuity values in the study group in the preoperative and postoperative periods (P>0.05). In contrast, uncorrected vision acuity values were significantly higher in patients during the postoperative period than the preoperative period (P>0.05). CONCLUSIONS The effects of vision correction with the Femto-LASIK procedure after DALK demonstrate the safety and effectiveness of the procedure for patients.