Paraneoplastic acquired hemophilia A associated with hilar cholangiocarcinoma arising in an intraductal papillary neoplasm of the bile duct

Rev Esp Enferm Dig. 2023 Dec;115(12):729-731. doi: 10.17235/reed.2023.9562/2023.

Abstract

A 74-year-old female was admitted for painless jaundice. Laboratory tests showed hyperbilirubinemia, cholestasis, normal coagulation, and Ca19-9:163U/L. The CT-scan reported dilation of the intrahepatic and extrahepatic bile ducts secondary to a 24mm tumor in the intrapancreatic common bile duct. The magnetic cholangioresonance showed multiple endoluminal polypoid lesions, suggestive of intraductal papillary neoplasm of the bile duct (IPNB). The endoscopic bile duct brushing was non-conclusive.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bile Duct Neoplasms* / complications
  • Bile Duct Neoplasms* / diagnostic imaging
  • Bile Duct Neoplasms* / pathology
  • Bile Ducts, Intrahepatic / diagnostic imaging
  • Bile Ducts, Intrahepatic / pathology
  • Cholangiocarcinoma* / complications
  • Cholangiocarcinoma* / diagnostic imaging
  • Cholangiocarcinoma* / pathology
  • Female
  • Hemophilia A*
  • Humans
  • Klatskin Tumor* / pathology

Supplementary concepts

  • Factor 8 deficiency, acquired