Pipeline embolization devices for the treatment of nonsaccular aneurysms in pediatric patients

Jintao Han; Fei Liang; Yuxiang Zhang; Yupeng Zhang; Shikai Liang; Haoyu Zhu; Yuzhou Chang; Chao Ma; Lian Liu; Zichang Jia; Chuhan Jiang

doi:10.3389/fneur.2023.1115618

Pipeline embolization devices for the treatment of nonsaccular aneurysms in pediatric patients

Front Neurol. 2023 Feb 28:14:1115618. doi: 10.3389/fneur.2023.1115618. eCollection 2023.

Authors

Affiliations

¹ Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing, China.
² Department of Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
³ Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Abstract

Objective: Pediatric nonsaccular aneurysms are rare but challenging lesions; pipeline embolization devices (PEDs) are their potential treatment option. In this study, we aimed to evaluate the safety and efficacy of PEDs for treatment of these aneurysms.

Methods: We retrospectively selected pediatric patients with nonsaccular aneurysms treated using PEDs between June 2015 and July 2021 from our prospectively maintained database. For each patient, demographics, aneurysm characteristics, procedure details, and clinical and angiographic follow-up data were collected and summarized.

Results: This study included 16 pediatric patients with 16 nonsaccular aneurysms treated with PEDs. A median clinical follow-up time of 1,376 days was achieved in 93.75% of the patients. The complication rate of the included patients was 25%, with two patients developing mass effect, one patient undergoing major ischemic stroke, and one patient experiencing stent foreshortening after the procedure. The complete occlusion rate of aneurysms without any neurologic sequelae was 93.33%, with a median angiographic follow-up period of 246 days. The mortality rate was 6.25%.

Conclusions: The use of PEDs to treat pediatric nonsaccular aneurysms is feasible, with a high rate of complete occlusion of the aneurysm and favorable follow-up outcomes.

Keywords: endovascular treatment; neurovascular diseases; nonsaccular aneurysms; pediatric diseases; pipeline embolization device.

Grants and funding

This work was supported by the Beijing Natural Science Foundation project (Grant No. 7212007) and the Key Research and Development Plan of Shandong Province (Grant No. A80476-01).